Amino-PEG4-acid
- Product Name
- Amino-PEG4-acid
- CAS No.
- 663921-15-1
- Chemical Name
- Amino-PEG4-acid
- Synonyms
- 1-AMino-3,6,9,12-tetraoxapentadecan-15-oic acid;NH2-PEG4-COOH;Amino-PEG4-acid;NH2-PEG4-CH2CH2COOH;3-[2-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]ethoxy]propionic acid;NH2-PEG4-PA;AMINE-PEG4-COOH;Amino-PEG4-COOH;amino-dPEG4-acid;Amino-dPEGx-acid
- CBNumber
- CB92501434
- Molecular Formula
- C11H23NO6
- Formula Weight
- 265.3
- MOL File
- 663921-15-1.mol
Amino-PEG4-acid Property
- Boiling point:
- 409.6±40.0 °C(Predicted)
- Density
- 1.134±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 4.28±0.10(Predicted)
- form
- powder
- color
- White
- InChI
- InChI=1S/C11H23NO6/c12-2-4-16-6-8-18-10-9-17-7-5-15-3-1-11(13)14/h1-10,12H2,(H,13,14)
- InChIKey
- DKUZHSDZSMQOGQ-UHFFFAOYSA-N
- SMILES
- C(O)(=O)CCOCCOCCOCCOCCN
Safety
- HS Code
- 2942000090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
N-Bromosuccinimide Price
- Product number
- QBD10244
- Product name
- Amino-dPEG®4-acid
- Purity
- >95% (HPLC)
- Packaging
- 100MG
- Price
- $170
- Updated
- 2024/03/01
- Product number
- H289595
- Product name
- H2N-Dpeg(4)-COOH
- Packaging
- 100mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- BP-20423
- Product name
- Amino-PEG4-acid
- Purity
- 98%
- Packaging
- 1g
- Price
- $320
- Updated
- 2021/12/16
- Product number
- 10244
- Product name
- Amino-dPEG®₄-acid
- Packaging
- 1000mg
- Price
- $350
- Updated
- 2021/12/16
- Product number
- AS114327
- Product name
- H2N-PEG4-CH2CH2COOH
- Purity
- 97+%
- Packaging
- 1g
- Price
- $398
- Updated
- 2021/12/16
Amino-PEG4-acid Chemical Properties,Usage,Production
Description
Amino-PEG4-acid is a very popular PEG linker. The amino group (NH2) is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The terminal carboxylic acid can react with primary amine groups of activated NHS ester to form a stable amide bond, long PEG spacer increases reagent's solubility in aqueous media.
Uses
H2N-Dpeg(4)-COOH, can be used in optical imaging of integrin αvβ3 expression with near-infrared fluorescent RGD dimer with tetra(ethylene glycol) linkers. Integrin αvβ3 plays great roles in tumor angiogenesis, invasion, and metastasis.
benefits
Amino-dPEG4-acid has a primary amine and propionic acid terminating opposite ends of a 16-atoms long (18.0 ?) polyethylene glycol (PEG) spacer. The single molecular weight PEG spacer is discrete (D = 1). Moreover, it is highly hydrophilic, and it imparts hydrophilicity to conjugates that incorporate it. Amino-dPEG4-acid is useful in many different applications, including peptide synthesis, surface modification, dendrimer construction, and small molecule modification.
References
1. Improving tumor-targeting capability and pharmacokinetics of (99m)Tc-labeled cyclic RGD dimers with PEG(4) linkers. DOI:10.1021/mp800150r
2. Short PEG-linkers improve the performance of targeted, activatable monoclonal antibody-indocyanine green optical imaging probes. DOI:10.1021/bc400050k
3. Microwave-mediated synthesis of labeled nucleotides with utility in the synthesis of DNA probes. DOI:10.1021/bc100013b
4. Improving tumor uptake and pharmacokinetics of (64)Cu-labeled cyclic RGD peptide dimers with Gly(3) and PEG(4) linkers. DOI:10.1021/bc800455p
Amino-PEG4-acid Preparation Products And Raw materials
Raw materials
Preparation Products
Amino-PEG4-acid Suppliers
View Lastest Price from Amino-PEG4-acid manufacturers
- Product
- α-amine-ω-propionic acid tetraethylene glycol 663921-15-1
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1Kg
- Purity
- 99.9%
- Supply Ability
- 200tons
- Release date
- 2024-04-08
- Product
- Amino-PEG4-COOH 663921-15-1
- Price
- US $0.00/g
- Min. Order
- 5g
- Purity
- >98.00%
- Supply Ability
- 25g
- Release date
- 2024-03-22
- Product
- α-amine-ω-propionic acid tetraethylene glycol 663921-15-1
- Price
- US $8.80/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 100kg
- Release date
- 2019-07-04